Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano-polyplexes
نویسندگان
چکیده
منابع مشابه
Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes.
Electrostatic complexation of a cationic MAPKAP kinase 2 inhibitory (MK2i) peptide with the anionic, pH-responsive polymer poly(propylacrylic acid) (PPAA) yields MK2i nano-polyplexes (MK2i-NPs) that significantly increase peptide uptake and intracellular retention. This study focused on elucidating the mechanism of MK2i-NP cellular uptake and intracellular trafficking in vascular smooth muscle ...
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Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2
BACKGROUND Mitogen-activated protein (MAP) kinases (or extracellular signal regulated kinases; Erks) and stress-activated protein (SAP) kinases mediate cellular responses to a wide variety of signals. In the Erk MAP kinase pathway, activation of MAP kinases takes place in the cytoplasm and the activated enzyme moves to the nucleus. This translocation to the nucleus is essential to MAP kinase si...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2018
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2018.04.045